科学家简介


顾小春

顾小春

北京大学分子医学南京转化研究院,研究员 地址:江苏南京市江北新区磐固路16号制剂加速器2栋 邮编:210032 邮箱:xiaochun.gu@seu.edu.cn

◆ 教育经历

2009年毕业于东南大学获得博士学位

 

◆ 工作经历

2014年-2016年,美国纽约州立大学石溪分校生物医学工程系访问学者和博士后研究

 

◆ 研发经历

自主搭建多通道光学成像平台,发现了胶质细胞在神经血管耦合中的新作用,制作了一系列的相关基因修饰动物疾病动物模型;多次受邀在国内外重要学术会议做报告。在Cell Reports, NeuroImage, J Neurosci, Theranostics等杂志发表相关SCI论文多篇。研究结果被F1000推荐阅读,承担国家863项目,国家自然科学基金项目,973项目的研究。主要荣誉:国家863计划课题组长;国家科技部重点领域创新团队核心成员;国家自然基金委创新研究群体研究骨干。

 

◆ 科研论文

1. Xiaochun Gu, Wei Chen, Alan P. Koretsky, Congwu Du, Yingtian Pan, “Synchronized Astrocytic Ca2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State” Cell Reports,2018, 23, 3878–3890(SCI 1区 IF=8.5)

2. Xiaochun Gu, Jiang You, Wei Chen, Alan P. Koretsky , Yingtian Pan, Congwu Du” Long-term multi-modal optical imaging of Neurovascular coupling for neuronal population using GCaMP6f ” NeuroImage 165 (2018) 251–264 (SCI 1区 IF=5.8)

3. W Chen, J You, Xiaochun Gu, C Du, Y Pan, "High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging", Scientific Reports, 2016:38786, DOI: 10.1038/srep38786,

4. Wu X*, Xiaochun Gu*, Han X, Du A, Jiang Y, Zhang X, Wang Y, Cao G, Zhao C. A Novel Function for FoxM1 in Interkinetic Nuclear Migration in the Developing Telencephalon And Anxiety-related Behavior. The Journal of Neuroscience. 2014 Jan; 34(4):1510-1522.(SCI 1区 IF=6.2 equal contribution)

5. Li M, Liu Y, Chen J, Liu T, Gu Z, Zhang J, Xiaochun Gu, Teng G, Yang F, Gu N Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics. Theranostics. 2018 Sep 9;8(18):4870-4883. (SCI 1区 IF=8.8)

6. Nie B, Chen K, Zhao S, Liu J, Xiaochun Gu, Yao Q, Hui J, Zhang Z, Teng G, Zhao C, Shan B . A Rat Brain MRI Template with Digital Stereotaxic Atlas of Fine Anatomical Delineations in Paxinos Space and its Automated Application in Voxel-Wise Analysis. Human Brain Mapping. 2013 Jun; 34(6):1306-18.

7. Xiaochun Gu, Liu B, Wu X, Yan Y, Zhang Y, Wei Y,. Pleasure SJ, Zhao C. Inducible Genetic Lineage Tracing of Cortical Hem Derived Cajal-Retzius Cells Reveals Novel Properties. PLoS ONE. 2011;6(12):e28653.(F1000 推荐阅读)

8. Xiaochun Gu, Yan Yan, Hanlin Li, Dongyang He, Samuel J. Pleasure, Chunjie Zhao Characterization of the Frizzled10-CreERTM Transgenic Mouse: An Inducible Cre Line for the Study of Cajal–Retzius Cell Development Genesis (2009)47(3): 210-216

9. Yan, Y., Li, Y., Hu, C., Xiaochun Gu., Liu, J., Hu, Y-A., Yang, Y., Wei, Y., Zhao, C., Expression of Frizzled10 in mouse central nervous system, Gene Expression Patterns (2009), 9(3): 173-177

10. Xiaochun Gu, Dongyang He, Yiping Li, Chuanyin Hu, Yu-sheng Wei, Guang Liu, Depei Liu, Samuel J. Pleasure, Wei Xie, and Chunjie Zhao . Generation of Frizzled10-Cre Transgenic Mouse Line: A Useful Tool for the Study of Dorsal Telencephalic Development Genesis (2008)46:523–529

11. Gu X*, Chu T, Liu L, Han X. Genetic influences on white matter and metabolism abnormal change in Alzheimer's disease: Meta-analysis for neuroimaging research on presenilin 1 mutation. Clin Neurol Neurosurg. 2019 Feb;177:47-53(第一和通讯作者).